|
|
L-proline <=> D-proline
|
5.1.1.4
proline racemase
5.1.1.8
4-hydroxyproline epimerase
|
–
–
|
BMK
|
|
BRENDA:
BR172
KEGG:
R01255
MetaCyc:
PROLINE-RACEMASE-RXN
SABIO-RK:
1473
|
|
|
|
L-ornithine <=> L-proline + NH3
|
4.3.1.12
ornithine cyclodeaminase
|
–
|
BMK
|
|
BRENDA:
BR3424
KEGG:
R00671
MetaCyc:
ORNITHINE-CYCLODEAMINASE-RXN
SABIO-RK:
1051
|
|
|
|
L-proline + NADP+ <=> DELTA1-pyrroline-2-carboxylate + NADPH + H+
|
1.5.1.1
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.21
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
1.5.1.25
thiomorpholine-carboxylate dehydrogenase
1.5.1.49
1-pyrroline-2-carboxylate reductase [NAD(P)H]
|
–
–
–
–
|
BMK
|
|
BRENDA:
BR36888
KEGG:
R01249
MetaCyc:
PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN;
RXN-16268
SABIO-RK:
1469
|
|
|
|
L-proline + NAD+ <=> DELTA1-pyrroline-2-carboxylate + NADH + H+
|
1.5.1.1
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.49
1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.B5
|
–
–
–
|
K
|
|
BRENDA:
BR36888-a
KEGG:
R01246
MetaCyc:
PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN_WOP
SABIO-RK:
1467
|
|
|
|
L-proline + NADP+ <=> L-pyrroline-5-carboxylate + NADPH + H+
|
1.5.1.2
pyrroline-5-carboxylate reductase
|
–
|
BMK
|
|
BRENDA:
BR36895
KEGG:
R01251
MetaCyc:
PYRROLINECARBREDUCT-RXN
SABIO-RK:
1470
|
|
|
|
L-proline + NAD+ <=> L-pyrroline-5-carboxylate + NADH + H+
|
1.2.1.88
L-glutamate gamma-semialdehyde dehydrogenase
1.5.1.2
pyrroline-5-carboxylate reductase
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
1.5.5.2
proline dehydrogenase
|
–
–
–
–
|
K
|
|
BRENDA:
BR36895-a;
BS439688
KEGG:
R01248
MetaCyc:
PYRROLINECARBREDUCT-RXN_WOP
SABIO-RK:
1468
|
|
|
|
L-proline + 2-oxoglutarate + O2 <=> cis-3-hydroxy-L-proline + succinate + CO2
|
1.14.11.28
proline 3-hydroxylase
|
–
|
|
|
BRENDA:
BR48760
KEGG:
R09572
MetaCyc:
1.14.11.28-RXN
|
|
|
|
L-prolinamide + H2O <=> L-proline + NH3
|
3.5.1.101
L-proline amide hydrolase
3.5.1.13
aryl-acylamidase
|
–
–
|
|
|
BRENDA:
BR49105
KEGG:
R09650
MetaCyc:
RXN-10758
|
|
|
|
L-proline + 2-oxoglutarate + O2 <=> cis-4-hydroxyproline + succinate + CO2
|
1.14.11.56
L-proline cis-4-hydroxylase
|
–
|
|
|
BRENDA:
BR49142
KEGG:
R11594
MetaCyc:
RXN-14244
|
|
|
|
L-proline + 2-oxoglutarate + O2 <=> trans-4-hydroxy-L-proline + succinate + CO2
|
1.14.11.2
procollagen-proline 4-dioxygenase
1.14.11.57
L-proline trans-4-hydroxylase
|
–
–
|
K
|
|
BRENDA:
BR51935;
BS288710
KEGG:
R01252
MetaCyc:
RXN490-3641
|
|
|
|
L-proline + ATP + H+ <=> (L-prolyl)adenylate + diphosphate
|
6.2.1.53
L-proline---[L-prolyl-carrier protein] ligase
|
–
|
M
|
|
BRENDA:
BR52378
KEGG:
R12056
MetaCyc:
RXN-19079
|
|
|
|
ATP + L-proline + H2O <=> ADP + phosphate + L-proline + H+
|
7.4.2
7.4.2.1
ABC-type polar-amino-acid transporter
7.4.2.2
ABC-type nonpolar-amino-acid transporter
|
–
–
–
|
|
|
BRENDA:
BS165500
MetaCyc:
ABC-26-RXN
|
|
|
|
Gly-Pro + H2O <=> glycine + L-proline
|
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
3.4.24.54
mucrolysin
|
–
–
–
–
|
|
|
BRENDA:
BS17158
MetaCyc:
RXN0-6988
SABIO-RK:
12810
|
|
|
|
L-proline + FAD <=> L-pyrroline-5-carboxylate + FADH2
|
1.5
1.5.5.2
proline dehydrogenase
1.5.8
1.5.99.B2
|
–
–
–
–
|
BK
|
|
BRENDA:
BS389060
KEGG:
R10507
MetaCyc:
RXN-21556
|
|
|
|
ubiquinone + L-proline <=> ubiquinol + H+ + L-pyrroline-5-carboxylate
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
M
|
|
BRENDA:
BS426587
MetaCyc:
RXN0-7008
|
|
|
|
L-proline + a_quinone <=> L-pyrroline-5-carboxylate + a_quinol
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
BK
|
|
BRENDA:
BR36918
KEGG:
R01253
|
|
|
|
ATP + L-proline + tRNAMet <=> AMP + diphosphate + L-prolyl-tRNAPro
|
6.1.1.15
proline---tRNA ligase
6.1.1.17
glutamate---tRNA ligase
|
–
–
|
BK
|
|
BRENDA:
BR45
KEGG:
R03661
SABIO-RK:
404
|
|
|
|
N-acetylproline + H2O <=> acetate + L-proline
|
3.5.1.14
N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.15
aspartoacylase
|
–
–
|
|
|
BRENDA:
BS140345
SABIO-RK:
8139
|
|
|
|
Pro-p-nitroanilide + H2O <=> L-proline + 4-nitroaniline
|
3.3.2.6
leukotriene-A4 hydrolase
3.4.11.1
leucyl aminopeptidase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.14
cytosol alanyl aminopeptidase
3.4.11.15
aminopeptidase Y
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.20
aminopeptidase Ey
3.4.11.22
aminopeptidase I
3.4.11.24
aminopeptidase S
3.4.11.5
prolyl aminopeptidase
3.4.11.B3
3.4.11.B9
3.4.14.5
dipeptidyl-peptidase IV
3.4.21.26
prolyl oligopeptidase
|
–
–
–
–
–
–
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS14582
SABIO-RK:
12236
|
|
|
|
Pro-Phe + H2O <=> L-proline + L-phenylalanine
|
3.4.11.13
clostridial aminopeptidase
3.4.11.5
prolyl aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
–
|
|
|
BRENDA:
BS36298
SABIO-RK:
10587
|
|
|
|
Arg-Pro + H2O <=> L-arginine + L-proline
|
3.4.11.6
aminopeptidase B
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
|
|
|
BRENDA:
BS36365
SABIO-RK:
11276
|
|
|
|
Pro-Pro + H2O <=> L-proline
|
3.4.11.5
prolyl aminopeptidase
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
–
|
|
|
BRENDA:
BS36381
SABIO-RK:
11280
|
|
|
|
Leu-Pro + H2O <=> L-leucine + L-proline
|
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
|
|
|
BRENDA:
BS36382
SABIO-RK:
11084;
11275
|
|
|
|
Phe-Pro + H2O <=> L-phenylalanine + L-proline
|
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
|
|
|
BRENDA:
BS36384
SABIO-RK:
11277
|
|
|
|
Val-Pro + H2O <=> L-valine + L-proline
|
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
|
|
|
BRENDA:
BS36385
SABIO-RK:
11278
|
|
|
|
Ser-Pro + H2O <=> L-serine + L-proline
|
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
|
|
|
BRENDA:
BS36386
SABIO-RK:
12812
|
|
|
|
Ala-Pro + H2O <=> L-alanine + L-proline
|
3.4.11.5
prolyl aminopeptidase
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.5
Xaa-methyl-His dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
–
|
|
|
BRENDA:
BS36391
SABIO-RK:
12811
|
|
|
|
Pro-Hyp + H2O <=> L-proline + L-hydroxyproline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS36455
SABIO-RK:
12814
|
|
|
|
Lys-Pro + H2O <=> L-lysine + L-proline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS394405
SABIO-RK:
11279
|
|
|
|
Arg-Pro-Pro + H2O <=> Arg-Pro + L-proline
|
3.4.11.9
Xaa-Pro aminopeptidase
|
–
|
|
|
BRENDA:
BS405566
SABIO-RK:
15463
|
|
|
|
L-proline + H2O + O2 <=> 2-Oxopentanoate + NH3 + H2O2
|
1.4.3.2
L-amino-acid oxidase
1.4.3.3
D-amino-acid oxidase
1.5.3.7
L-pipecolate oxidase
|
–
–
–
|
|
|
BRENDA:
BS441542
SABIO-RK:
10070
|
|
|
|
peptide + H2O <=> L-proline + peptide
|
3.4.11.5
prolyl aminopeptidase
|
–
|
K
|
|
KEGG:
R00135
|
|
|
|
L-proline + pC3'p + ATP <=> (L-prolyl)-[peptidyl-carrier_protein] + AMP + diphosphate
|
6.2.1.53
L-proline---[L-prolyl-carrier protein] ligase
|
–
|
K
|
|
KEGG:
R06746
|
|
|
|
L-tryptophan + L-proline + 2 ATP <=> brevianamide_F + 2 AMP + 2 diphosphate
|
not assigned
|
–
|
K
|
|
KEGG:
R10661
|
|
|
|
ATP + L-proline + Aryl-carrier_protein <=> AMP + diphosphate + 3,4-dihydroxybenzoyl-[aryl-carrier_protein]
|
6.2.1.62
3,4-dihydroxybenzoate---[aryl-carrier protein] ligase
|
–
|
|
|
KEGG:
R12575
|
|
|
|
peptide_with_an_N-terminal_L-proline + H2O <=> L-proline + peptide
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.5-RXN
|
|
|
|
Xaa-Pro + H2O <=> proteinogenic_amino_acid + L-proline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
MetaCyc:
3.4.13.9-RXN
|
|
|
|
tRNAMet + L-proline + ATP <=> L-prolyl-[tRNAPro] + diphosphate + AMP
|
6.1.1.15
proline---tRNA ligase
|
–
|
M
|
|
MetaCyc:
PROLINE--TRNA-LIGASE-RXN
|
|
|
|
N-methyl-L-proline + O2 + H2O <=> L-proline + formaldehyde + H2O2
|
1.5.3
|
–
|
M
|
|
MetaCyc:
R502-RXN
|
|
|
|
indole-3-acetic_acid + L-proline + ATP <=> H+ + (indol-3-yl)acetyl-L-proline + AMP + diphosphate
|
6.3
|
–
|
|
|
MetaCyc:
RXN-10434
|
|
|
|
lysergate + L-alanine + L-phenylalanine + L-proline + H+ + acceptor <=> ergotamine + H2O + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-11399
|
|
|
|
electron-transfer_quinone + L-proline <=> electron-transfer_quinol + H+ + L-pyrroline-5-carboxylate
|
1.5.5.2
proline dehydrogenase
|
–
|
M
|
|
MetaCyc:
RXN-14903
|
|
|
|
L-tryptophan + L-proline + ATP <=> brevianamide_F + ADP + phosphate + H+
|
6.3.3
|
–
|
M
|
|
MetaCyc:
RXN-15642
|
|
|
|
L-proline + holo-[PigG_prolyl-carrier_protein] + ATP <=> L-prolyl-[PigG_prolyl-carrier_protein] + AMP + diphosphate
|
6.2.1.53
L-proline---[L-prolyl-carrier protein] ligase
|
–
|
M
|
|
MetaCyc:
RXN-15779
|
|
|
|
R-2-hydroxy-3-methylpentanoate-methylvaline-phenylalanine-methylphenylalanyl-[acp] + ATP + L-proline <=> R-2-hydroxy-3-methylpentanoate-methylvaline-phenylalanine-methylphenylalanine-prolyl-[acp] + AMP + diphosphate + H+
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-16641
|
|
|
|
S-adenosyl-L-methionine + 3-hydroxy-4-methyl-anthranilyl-L-threonyl-D-valyl-[AcmD_acyl-carrier_protein] + L-valine + L-proline + glycine + ATP <=> 3-hydroxy-4-methyl-anthranilate_pentapeptide_lactone + S-adenosyl-L-homocysteine + holo-[AcmD_acyl-carrier_protein] + ADP + phosphate + H+
|
6.3.1
|
–
|
M
|
|
MetaCyc:
RXN-17073
|
|
|
|
L-proline + holo-[PltL_prolyl-carrier_protein] + ATP <=> L-prolyl-[PltL_prolyl-carrier_protein] + AMP + diphosphate
|
6.2.1.53
L-proline---[L-prolyl-carrier protein] ligase
|
–
|
|
|
MetaCyc:
RXN-19065
|
|
|
|
L-proline + holo-[L-prolyl-carrier_protein] + ATP <=> (L-prolyl)-[peptidyl-carrier_protein] + AMP + diphosphate
|
6.2.1.53
L-proline---[L-prolyl-carrier protein] ligase
|
–
|
|
|
MetaCyc:
RXN-19068
|
|
|
|
L-proline + holo-[Bmp1_prolyl-carrier_protein] + ATP <=> L-prolyl-[Bmp1_prolyl-carrier_protein] + AMP + diphosphate
|
6.2.1.53
L-proline---[L-prolyl-carrier protein] ligase
|
–
|
M
|
|
MetaCyc:
RXN-19069
|
|
|
|
D-phenylalanyl-[gramicidin-S_synthetase] + L-proline + L-valine + L-ornithine + L-leucine + ATP <=> D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-[NRPS-pcp] + AMP + diphosphate + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9677
|
|
|
|
L-pyrroline-5-carboxylate + e- + H+ <=> L-proline
|
not assigned
|
–
|
|
|
MetaCyc:
RXN0-7005
|
|
|
|
L-proline + ATP + holo-[RedO_prolyl-carrier_protein] <=> L-prolyl-[RedO_prolyl-carrier_protein] + diphosphate + AMP + H+
|
6.2.1.53
L-proline---[L-prolyl-carrier protein] ligase
|
–
|
M
|
|
MetaCyc:
RXN1A0-6104
|
|
|
|
Na+ + L-proline <=> Na+ + L-proline
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN-118
|
|
|
|
H+ + L-proline <=> H+ + L-proline
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN-29
|
|
|
|
Pro-Trp + H2O <=> L-proline + L-tryptophan
|
3.4.11.16
Xaa-Trp aminopeptidase
3.4.11.5
prolyl aminopeptidase
|
–
–
|
|
|
BRENDA:
BS36301
|
|
|
|
L-proline + menadione <=> L-pyrroline-5-carboxylate + menadiol
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS451692
|
|
|
|
alpha-MSH + H2O <=> alpha-MSH(1-12) + L-proline
|
3.4.21.26
prolyl oligopeptidase
|
–
|
|
|
BRENDA:
BS411614
|
|
|
|
Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys-Lys + H2O <=> L-proline + Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys-Lys
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS450505
|
|
|
|
L-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O <=> L-proline + Pro-7-amido-4-carbamoylmethylcoumarin
|
3.4.11.9
Xaa-Pro aminopeptidase
|
–
|
|
|
BRENDA:
BS450188
|
|
|
|
benzyloxycarbonyl-Phe-Pro + H2O <=> benzyloxycarbonyl-Phe + L-proline
|
3.4.16.5
carboxypeptidase C
|
–
|
|
|
BRENDA:
BS361644
|
|
|
|
Benzyloxycarbonyl-Gly-Pro + H2O <=> Benzyloxycarbonyl-Gly + L-proline
|
3.4.16.5
carboxypeptidase C
|
–
|
|
|
BRENDA:
BS361655
|
|
|
|
Pro-Gly-Gly-Gly + H2O <=> L-proline + Gly-Gly-Gly
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS450501
|
|
|
|
L-proline + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O <=> L-pyrroline-5-carboxylate + reduced_iodonitrotetrazolium_chloride
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS397651
|
|
|
|
L-proline + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O <=> 1-pyrroline-5-carboxylate + reduced_p-iodonitro-tetrazolium_violet
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS426586
|
|
|
|
L-proline + iodonitrotetrazolium_chloride + H2O <=> 1-pyrroline-5-carboxylate + reduced_4-iodonitrotetrazolium_violet
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS426590
|
|
|
|
Pro-Leu-Gly-NH2 + H2O <=> L-proline + Leu-Gly-NH2
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36305
|
|
|
|
thiamine + L-proline <=> 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyrrolidine-2-carboxylic_acid
|
2.5.1.2
thiamine pyridinylase
|
–
|
|
|
BRENDA:
BS353790
|
|
|
|
L-proline + 2,6-dichlorphenolindophenol <=> L-pyrroline-5-carboxylate + reduced_2,6-dichlorphenolindophenol
|
1.5.5.2
proline dehydrogenase
|
–
|
|
|
BRENDA:
BS441544
|
|
|
|
Pro-Phe-NH2 + H2O <=> L-proline + Phe-NH2
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36297
|
|
|
|
Pro-Phe-Gly-Lys + H2O <=> L-proline + Phe-Gly-Lys
|
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.20
aminopeptidase Ey
3.4.11.5
prolyl aminopeptidase
|
–
–
–
|
|
|
BRENDA:
BS36304
|
|
|
|
(Pro-Gly-Pro)4-6 + H2O <=> L-proline + Gly-Pro-(Pro-Gly-Pro)3-5
|
3.4.11.13
clostridial aminopeptidase
|
–
|
|
|
BRENDA:
BS64807
|
|
|
|
(Pro-Gly-Pro)4-6-OMe + H2O <=> L-proline + Gly-Pro-(Pro-Gly-Pro)3-5-OMe
|
3.4.11.13
clostridial aminopeptidase
|
–
|
|
|
BRENDA:
BS64808
|
|
|
|
L-proline + H2O <=> L-pyrroline-5-carboxylate + H2O2
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS397650
|
|
|
|
poly(L-Pro) + H2O <=> L-proline
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36309
|
|
|
|
5-L-glutamyl-L-proline <=> 5-oxoproline + L-proline
|
4.3.2.9
gamma-glutamylcyclotransferase
|
–
|
|
|
BRENDA:
BS321729
|
|
|
|
benzyloxycarbonyl-Pro-Ala-Ala-Ala-Pro + H2O <=> benzyloxycarbonyl-Pro-Ala-Ala-Ala + L-proline
|
3.4.22.16
cathepsin H
|
–
|
|
|
BRENDA:
BS355553
|
|
|
|
L-proline + 2,6-dichlorophenolindophenol + H2O <=> L-pyrroline-5-carboxylate + reduced_2,6-dichlorophenolindophenol
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
|
|
BRENDA:
BS377069
|
|
|
|
L-proline + oxidized_2,6-dichlorophenolindophenol + H2O <=> L-pyrroline-5-carboxylate + reduced_2,6-dichlorophenolindophenol
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS428746
|
|
|
|
L-proline + 2,6-dichlorophenolindophenol + H2O <=> 1-pyrroline-5-carboxylate + reduced_2,6-dichlorophenolindophenol
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
|
|
BRENDA:
BS426585
|
|
|
|
L-proline + oxidized_dichlorophenolindophenol <=> 1-pyrroline-5-carboxylate + reduced_2,6-dichlorophenolindophenol
|
1.5.5.2
proline dehydrogenase
|
–
|
|
|
BRENDA:
BS405644
|
|
|
|
PPGFSPFR + H2O <=> L-proline + PGFSPFR
|
3.4.11.5
prolyl aminopeptidase
3.4.11.9
Xaa-Pro aminopeptidase
|
–
–
|
|
|
BRENDA:
BS364844
|
|
|
|
Pro-Leu-Gly + H2O <=> Leu-Gly + L-proline
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS412760
|
|
|
|
L-Pro-OBzl + H2O <=> L-proline + benzoate
|
3.1.1.43
alpha-amino-acid esterase
|
–
|
|
|
BRENDA:
BS401280
|
|
|
|
Pro-Ala-Pro-Tyr-Lys-amide + H2O <=> L-proline + Ala-Pro-Tyr-Lys-amide
|
3.4.11.22
aminopeptidase I
|
–
|
|
|
BRENDA:
BS364804
|
|
|
|
Pro-2-naphthylamide + H2O <=> L-proline + 2-Naphthylamine
|
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.20
aminopeptidase Ey
3.4.11.22
aminopeptidase I
3.4.11.5
prolyl aminopeptidase
3.4.19.1
acylaminoacyl-peptidase
3.5.1.57
tryptophanamidase
|
–
–
–
–
–
–
|
|
|
BRENDA:
BS140603
|
|
|
|
Pro-2-naphthylamide + H2O <=> L-proline + 2-naphthylamide
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS412747
|
|
|
|
L-proline + ferricyanide + H2O <=> L-pyrroline-5-carboxylate + ferrocyanide
|
1.5.5.2
proline dehydrogenase
|
–
|
|
|
BRENDA:
BS377071
|
|
|
|
L-proline + ferricyanide <=> 1-pyrroline-5-carboxylate + ferrocyanide
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS426588
|
|
|
|
Pro-Ile + H2O <=> L-proline + L-isoleucine
|
3.4.13.18
cytosol nonspecific dipeptidase
|
–
|
|
|
BRENDA:
BS94933
|
|
|
|
Pro-D-Ala + H2O <=> L-proline + D-alanine
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36300
|
|
|
|
Pro-D-Phe + H2O <=> L-proline + D-Phe
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36306
|
|
|
|
Pro-Lys + H2O <=> L-proline + L-lysine
|
3.4.11.5
prolyl aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
|
–
–
|
|
|
BRENDA:
BS36303
|
|
|
|
Pro-Leu-NH2 + H2O <=> L-proline + Leu-NH2
|
3.4.13.18
cytosol nonspecific dipeptidase
|
–
|
|
|
BRENDA:
BS94931
|
|
|
|
Pro-Phe-Arg-4-methylcoumarin_7-amide + H2O <=> L-proline + Phe-Arg-4-methylcoumaryl-7-amide
|
3.4.11.15
aminopeptidase Y
|
–
|
|
|
BRENDA:
BS361383
|
|
|
|
(Pro-Gly-Pro)n + H2O <=> L-proline + Gly-Pro-(Pro-Gly-Pro)n-1
|
3.4.11.13
clostridial aminopeptidase
|
–
|
|
|
BRENDA:
BS380809
|
|
|
|
benzyloxycarbonyl-Arg-Pro + H2O <=> Benzyloxycarbonyl-Arg + L-proline
|
3.4.16.5
carboxypeptidase C
|
–
|
|
|
BRENDA:
BS361639
|
|
|
|
Pro-Val + H2O <=> L-proline + L-valine
|
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
|
|
|
BRENDA:
BS385051
|
|
|
|
L-Pro-L-Glu + H2O <=> L-proline + L-glutamate
|
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
|
|
|
BRENDA:
BS382663
|
|
|
|
PLSRTLSVAAKK + H2O <=> LSRTLSVAAKK + L-proline
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS382587
|
|
|
|
Tyr-Pro + H2O <=> L-tyrosine + L-proline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS36452
|
|
|
|
Pro-Gly-Gly + H2O <=> L-proline + Gly-Gly
|
3.4.11.13
clostridial aminopeptidase
3.4.11.5
prolyl aminopeptidase
|
–
–
|
|
|
BRENDA:
BS64787
|
|
|
|
His-Pro + H2O <=> L-histidine + L-proline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS36454
|
|
|
|
Ile-Pro + H2O <=> L-isoleucine + L-proline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS36443
|
|
|
|
L-proline + 2-oxoglutarate + O2 <=> trans-L-3-hydroxyproline + succinate
|
1.14.11.7
procollagen-proline 3-dioxygenase
|
–
|
|
|
BRENDA:
BS377070
|
|
|
|
Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O <=> Benzyloxycarbonyl-Gly-Pro-Leu-Gly + L-proline
|
3.4.16.5
carboxypeptidase C
|
–
|
|
|
BRENDA:
BS391444
|
|
|
|
angiotensin_I + H2O <=> DRVYIH + L-proline + Phe-His-Leu
|
3.4.24.42
atrolysin C
|
–
|
|
|
BRENDA:
BS17064
|
|
|
|
L-Prolyl-peptide + H2O <=> L-proline + peptide
|
3.4.11.5
prolyl aminopeptidase
3.4.11.9
Xaa-Pro aminopeptidase
|
–
–
|
|
|
BRENDA:
BS36295
|
|
|
|
Pro-Leu + H2O <=> L-proline + L-leucine
|
3.4.11.1
leucyl aminopeptidase
3.4.11.13
clostridial aminopeptidase
3.4.11.5
prolyl aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
–
–
|
|
|
BRENDA:
BS36296
|
|
|
|
Pro-Gly-Pro + H2O <=> L-proline + Gly-Pro
|
3.4.11.13
clostridial aminopeptidase
|
–
|
|
|
BRENDA:
BS64785
|
|
|
|
DL-Proline_amide + H2O <=> NH3 + L-proline
|
3.5.1.4
amidase
3.5.1.56
N,N-dimethylformamidase
|
–
–
|
|
|
BRENDA:
BS140588
|
|
|
|
L-Pro-4-(phenylazo)phenylamide + H2O <=> L-proline + 4-phenylazophenylamine
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36313
|
|
|
|
L-Pro-L-Pro-4-(phenylazo)phenylamide + H2O <=> L-proline + 4-phenylazophenylamine
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36314
|
|
|
|
N-L-Pro-2-naphthylamide + H2O <=> L-proline + naphthylamine
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36310
|
|
|
|
Xaa-Pro + H2O <=> an_L-amino_acid + L-proline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS364862
|
|
|
|
Ala-Ala-Ala-Pro + H2O <=> Ala-Ala-Ala + L-proline
|
3.4.15.1
peptidyl-dipeptidase A
|
–
|
|
|
BRENDA:
BS64970
|
|
|
|
Lys-Ala-Pro + H2O <=> Lys-Ala + L-proline
|
3.4.14.2
dipeptidyl-peptidase II
|
–
|
|
|
BRENDA:
BS73974
|
|
|
|
Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O <=> Benzyloxycarbonyl-Gly-Pro + L-leucine + glycine + L-proline
|
3.4.22.B60
3.4.22.B62
|
–
–
|
|
|
BRENDA:
BS418123
|
|
|
|
Gly-Pro-7-amido-4-trifluoromethylcoumarin + H2O <=> glycine + L-proline + 7-amino-4-trifluoromethylcoumarin
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS36458
|
|
|
|
Pro-Gly + H2O <=> L-proline + glycine
|
3.4.11.5
prolyl aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.5
Xaa-methyl-His dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
–
|
|
|
BRENDA:
BS36299
|
|
|
|
Pro-Phe-Pro + H2O <=> L-proline + Phe-Pro
|
3.4.11.10
bacterial leucyl aminopeptidase
|
–
|
|
|
BRENDA:
BS64758
|
|
|
|
Pro-7-amido-4-methylcoumarin <=> L-proline + 7-amino-4-methylcoumarin
|
3.4.11.1
leucyl aminopeptidase
3.4.11.14
cytosol alanyl aminopeptidase
3.4.11.5
prolyl aminopeptidase
|
–
–
–
|
|
|
BRENDA:
BS361359
|
|
|
|
proline-7-amido-4-methylcoumarin + H2O <=> L-proline + 7-amino-4-methylcoumarin
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS364825
|
|
|
|
L-proline-4-methylcoumaryl-7-amide + H2O <=> L-proline + 7-amino-4-methylcoumarin
|
3.3.2.6
leukotriene-A4 hydrolase
3.4.11.1
leucyl aminopeptidase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.14
cytosol alanyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.4
tripeptide aminopeptidase
3.4.11.5
prolyl aminopeptidase
3.4.11.6
aminopeptidase B
3.4.11.7
glutamyl aminopeptidase
|
–
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS392405
|
|
|
|
L-proline + acceptor <=> L-pyrroline-5-carboxylate + reduced_acceptor
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
B
|
|
BRENDA:
BR51015
|
|
|
|
Pro-4-methoxy-beta-naphythylamide + H2O <=> L-proline + 4-methoxy-2-naphthylamine
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS450496
|
|
|
|
L-Pro-Gly-Gly + H2O <=> L-proline + Gly-Gly
|
3.4.11.4
tripeptide aminopeptidase
|
–
|
|
|
BRENDA:
BS452886
|
|
|
|
L-Pro-L-Leu-Gly-NH2 + H2O <=> L-proline + L-Leu-Gly-NH2
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
BRENDA:
BS452889
|
|
|
|
L-Pro-beta-naphthylamide + H2O <=> L-proline + 2-Naphthylamine
|
3.4.22.16
cathepsin H
|
–
|
|
|
BRENDA:
BS366697
|
|
|
|
L-proline + cytochrome_c + H2O <=> L-pyrroline-5-carboxylate + ferricytochrome_c
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
|
|
BRENDA:
BS397649
|
|
|
|
ATP + L-proline + L-glutamine <=> ADP + phosphate + L-Pro-L-Gln
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428328
|
|
|
|
ATP + L-proline + beta-Alanine <=> ADP + phosphate + beta-alanyl-L-proline
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428323
|
|
|
|
ATP + L-proline + L-asparagine <=> ADP + phosphate + L-prolyl-L-asparagine
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428325
|
|
|
|
ATP + L-proline + L-isoleucine <=> ADP + phosphate + L-prolyl-L-isoleucine
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428330
|
|
|
|
ATP + L-proline + L-threonine <=> ADP + phosphate + L-prolyl-L-threonine
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428334
|
|
|
|
ATP + L-tryptophan + L-proline <=> ADP + phosphate + Trp-Pro
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428352
|
|
|
|
ATP + H2O + L-proline-[L-proline-binding_protein][side_1] <=> ADP + phosphate + L-proline + [L-proline-binding_protein][side_1]
|
7.4.2.2
ABC-type nonpolar-amino-acid transporter
|
–
|
|
|
BRENDA:
BS444237
|
|
|
|
ATP + L-proline + L-glutamate <=> ADP + phosphate + L-Pro-L-Glu
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428327
|
|
|
|
ATP + L-tyrosine + L-proline <=> ADP + phosphate + YP
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428363
|
|
|
|
ATP + L-proline + glycine <=> ADP + phosphate + Pro-Gly
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428329
|
|
|
|
ATP + L-phenylalanine + L-proline <=> ADP + phosphate + Phe-Pro
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428316
|
|
|
|
ATP + L-proline + L-aspartate <=> ADP + phosphate + Pro-Asp
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428326
|
|
|
|
ATP + L-proline + L-valine <=> ADP + phosphate + Pro-Val
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428335
|
|
|
|
ATP + L-proline + L-alanine <=> ADP + phosphate + Pro-Ala
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428324
|
|
|
|
ATP + L-histidine + L-proline <=> ADP + phosphate + His-Pro
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408560
|
|
|
|
ATP + L-proline + L-methionine <=> ADP + phosphate + L-Pro-L-Met
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428332
|
|
|
|
ATP + L-proline + L-leucine <=> ADP + phosphate + Pro-Leu
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428331
|
|
|
|
ATP + L-proline + L-serine <=> ADP + phosphate + L-Pro-L-Ser
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428333
|
|
|
|
ATP + glycine + L-proline <=> ADP + phosphate + Gly-Pro
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408543
|
|
|
|
Pro-Met + H2O <=> L-proline + L-methionine
|
3.4.13.18
cytosol nonspecific dipeptidase
|
–
|
|
|
BRENDA:
BS94928
|
|
|
|
L-Pro-L-Met + H2O <=> L-proline + L-methionine
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS385045
|
|
|
|
(2-aminobenzoyl)-FFFP + H2O <=> (2-aminobenzoyl)-FFF + L-proline
|
3.4.18.1
cathepsin X
|
–
|
|
|
BRENDA:
BS365062
|
|
|
|
(Pro-Gly-Pro)n-methyl_ester + H2O <=> L-proline + Gly-Pro-(Pro-Gly-Pro)n-methyl_ester
|
3.4.11.13
clostridial aminopeptidase
|
–
|
|
|
BRENDA:
BS380810
|
|
|
|
Gly-Pro-4-nitroanilide + H2O <=> glycine + L-proline + 4-nitroaniline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS36459
|
|
|
|
L-proline + oxidized_phenazine_methosulfate <=> L-pyrroline-5-carboxylate + reduced_phenazine_methosulfate
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
|
|
BRENDA:
BS440304
|
|
|
|
Pro-Gly-Pro-Pro + H2O <=> L-proline + Gly-Pro-Pro
|
3.4.11.13
clostridial aminopeptidase
|
–
|
|
|
BRENDA:
BS64806
|
|
|
|
Thr-Pro + H2O <=> L-threonine + L-proline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS36451
|
|
|
|
Met-Pro + H2O <=> L-methionine + L-proline
|
3.4.11.18
methionyl aminopeptidase
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
|
|
|
BRENDA:
BS36383
|
|
|
|
Pro-Ser + H2O <=> L-proline + L-serine
|
3.4.13.18
cytosol nonspecific dipeptidase
|
–
|
|
|
BRENDA:
BS382669
|
|
|
|
L-Pro-L-Ser + H2O <=> L-proline + L-serine
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS385049
|
|
|
|
ATP + L-proline + L-tRNAPro <=> AMP + diphosphate + L-prolyl-tRNAPro
|
6.1.1.15
proline---tRNA ligase
|
–
|
|
|
BRENDA:
BS443164
|
|
|
|
ATP + L-proline + holo-[L-prolyl-carrier_protein] <=> AMP + diphosphate + L-prolyl-[L-prolyl-carrier_protein]
|
6.2.1.53
L-proline---[L-prolyl-carrier protein] ligase
|
–
|
|
|
BRENDA:
BR52377
|
|
|
|
ATP + L-proline + L-tRNAAla <=> AMP + diphosphate + L-prolyl-tRNAAla
|
6.1.1.15
proline---tRNA ligase
|
–
|
|
|
BRENDA:
BS443162
|
|
|
|
ATP + L-proline + L-tRNAProAla <=> AMP + diphosphate + L-prolyl-tRNAProAla
|
6.1.1.15
proline---tRNA ligase
|
–
|
|
|
BRENDA:
BS443163
|
|
|
|
ATP + L-proline + holo-[L-prolyl-carrier_protein_PltL] <=> AMP + diphosphate + L-prolyl-[L-prolyl-carrier_protein_PltL]
|
6.2.1.53
L-proline---[L-prolyl-carrier protein] ligase
|
–
|
|
|
BRENDA:
BS443161
|
|
|
|
ATP + L-proline + tRNAMet <=> AMP + diphosphate + L-prolylyl-tRNAGlu
|
6.1.1.15
proline---tRNA ligase
|
–
|
|
|
BRENDA:
BS442309
|
|
|
|
Asp-Pro + H2O <=> L-aspartate + L-proline
|
3.4.13.9
Xaa-Pro dipeptidase
|
–
|
|
|
BRENDA:
BS394252
|
|
|
|
Pro-Asp + H2O <=> L-proline + L-aspartate
|
3.4.11.5
prolyl aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
|
|
|
BRENDA:
BS36302
|
|
|
|
5-L-glutamyl-4-nitroanilide + L-proline <=> 4-nitroaniline + 5-L-glutamyl-L-proline
|
2.3.2.2
gamma-glutamyltransferase
|
–
|
|
|
BRENDA:
BS321646
|
|
|
|
5-L-glutamyl-4-nitroanilide + L-proline <=> 4-nitroaniline + 5-L-glutamyl-L-Pro
|
2.3.2.2
gamma-glutamyltransferase
|
–
|
|
|
BRENDA:
BS375989
|
|
|
|
Pro-Ala + H2O <=> L-proline + L-alanine
|
3.4.11.5
prolyl aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
|
|
|
BRENDA:
BS36307
|
|
|
|
Pro-Phe-Gly-Lys + H2O <=> L-proline + L-phenylalanine + Gly-Lys
|
3.4.11.20
aminopeptidase Ey
|
–
|
|
|
BRENDA:
BS382668
|
|